Antibiotic resistance profile of Escherichia Coli isolated from patients with urinary tract infections
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Abstract
Urinary tract infections (UTIs) are among the most common bacterial infections whether they are community or hospital acquired. Several risk factors are associated with UTIs, such as, amongothers, sex, previous UTIs, vaginal infections, and genetic susceptibility. In the present study, weanalyzed the resistance profile of Escherichia coli which is the bacterium frequently associated with urinary tract infections. E. coli strains were isolated by culture from urine from 150 episodes of urinary tract infections. Our results showed that among the 150 episodes tested, 102 were from females (69%) and 45 were from males (31%). The antibiogram results showed that E. coli strains exhibited high resistance against ampicillin and amoxicillin because these two antibiotics are the most widely used in the medical field. Imipenem and aminoglycosides, on the other hand, remain the most active molecules. Nevertheless, it is prudent to use these antibiotics, in order to reduce the risk of developing resistance against them.
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References
Akpabie A., Prieur B., 2001. Germes urinaires et leur sensibilité aux antibiotiques en gériatrie service de microbiologie/hygiène. Méd Mal Infect. 31 : 461-7.
Arana DM., Rubio M., Alós JI., 2017. Evolution of antibiotic multiresistance in Escherichia coli and Klebsiella pneumoniae isolates from urinary tract infections: A 12- year analysis (2003-2014). Enferm Infecc Microbiol Clin. 35:293-8.
Asadi Karam M.R., Habibi M., Bouzari S., 2019. Urinary tract infection: Pathogenicity, antibiotic resistance and development of effective vaccines against Uropathogenic Escherichia coli. Molecular Immunology. 108 : 56–67.
Benyagoub E., Benyagoub E., Berbaoui H., Rahmani C., Benyoussef L., 2013. Identification and study of the emergence of antibiotic resistance of microorganisms responsible for urinary tract infections in Bechar (Algeria) ScienceLib Editions Mersenne : Volume 5. N ° 131201 ISSN 2111-4706.
Bergogne-Bérézin E., 2006. Antibiothérapie des infections urinaires basses : bases cliniques, microbiologiques et pharmacologiques. ANTIBIOTIQUES. 8 : 51-62.
Bouzenoune F., Boudersa F., Bensaad A., Harkat F., Siad N., 2009. Urinary tract infections in Ain M’lila (Algeria). Antibiotic resistance of 239 strains isolated between 2006 and 2007. Médecine et maladies infectieuses. 39 : 142–143.
Brumbaugh AR., Smith SN., MobleyHL., 2013. Immunization with the yersiniabactin receptor, FyuA, protects against pyelonephritis in a murine model of urinary tract infection. Infect. Immun. 81: 3309–3316.
Dia ML., Chabouny H., Diagne R., Kâ R., Ba-Diallo A., Lô S., Gassama B., Cissé MF., Sow AI., 2015. Antibiotic susceptibility pattern of uropathogenic bacterial isolates in a Dakar Senegalese Teaching Hospital. Uro’Andro – Vol 1. N° 4. 212-217.
Dupeyron C., 2014. Guide de réalisation de l’ECBU, Bactériologie, hôpital Albertchenenvier P09.
Elfane M., Jebbar S., Daoudi N., Dollo D., Sodqi M., Chakib A., Ouladlahsen A., Marih L., Marhoum elfilali K., 2016. Infections urinaires nosocomiales : profil épidémiologique et bactériologique. Médecine et maladies infectieuses. 46 : 17-59.
Foxman B., 2002. Epidemiology of urinary tract infections: incidence, morbidity and economic costs. American Journal of Medicine. 113:5S-13S.
Gonthier R., 2000. Infection urinaire du sujet âgé. La Revue de Gériatrie, Tome 25, N°2 : 95-103.
Hannan TJ et al., 2012. Host–pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection. FEMS Microbiol Rev. 36:616– 648.
Hooton TM., 2012. Clinical practice. Uncomplicated urinary tract infection. N. Engl. J. Med. 366: 1028–1037.
Jeandel C et Blain H., 2004. Antibiotiques chez le sujet âgé, EMC, Médecine Akos, 5-0200
Kalantar E, Esmaeel Motlagh M, Lornejad H et al., 2008. Prevalence of urinary tract pathogens and antimicrobial susceptibility patterns in children at hospitals in Iran Archives of Clinical Infectious Diseases: Vol.3, issue 3; 149-153
Larabi K, Masmoudi A, Fendri C., 2003. Étude bactériologique et phénotypes de résistance des germes responsables d’infections urinaires dans un CHU de Tunis : à propos de 1930 cas. Med Mal Infect. 33:348–52.
Lavigne JP., Le Moing V., Sotto A., 2005. Quels antibiotiques utiliser en pratique courante dans les infections urinaires communautaires en France ? Spectra Biologie. 146:18—23.
Lichtenberger P, Hooton TM., 2008. Complicated urinary tract infections. Curr Infect Dis Rep.10:499–504.
Mann R., Mediati DG., Duggin IG., Harry EJ., Bottomley AL., 2017. Metabolic adaptations of uropathogenic E. coli in the urinary tract. Front. Cell. Infect. Microbiol. 7– 241.
Messai Y., Benhassine T., Naim M., Paul G., Bakour R., 2006. Prevalence of β-lactams resistance among Escherichia coli clinical isolates from a hospital in Algiers. Rev Esp Quimioterap.19:144–51.
Monnet DL., 2000. Antibiotic use and bacterial resistance. Ann Fr Anesth Reanim. 19: 409-17.
Thabet L., Messadi AA., Meddeb B., Mbarek M., Turki A., Ben Redjeb S., 2010. Profil bactériologique des infections urinaires chez la femme à l’Hôpital Aziza Othmana : étude à propos de 495 cas. La tunisie Medicale; Vol 88 (n°012). 898 – 901.
Yoneyama H., Katsumata R., 2006. Antibiotic resistance in bacteria and its future for novel antibiotic development. Biosci Biotechnol Biochem. 70:1060-75.
Yüksel S., Öztürk B., Kavaz A., Özcakar Z., Acar B., Güriz H., et al., 2006. Antibiotic resistance of urinary tract pathogens and evaluation of empirical treatment in Turkish children with urinary tract infections. Int J Antimicrob Agents. 28:413–6.